how much selenium per day

So, it is difficult to say who is average and normal and then suggest an ideal daily dosage of selenium. 53:120125. Am. Hurst, R., Hooper, L., Norat, T., Lau, R., Aune, D., Greenwood, D. C., & Fairweather-Tait, S. J. Experts, information and hot topics. Schrauzer, G. N. (2009). articles. The amount of selenium you need is: 75g a day for men (19 to 64 years) 60g a day for women (19 to 64 years) other information we have about you. We also use third-party cookies that help us analyze and understand how you use this website. Selenium and prostate cancer: systematic review and meta-analysis. Available from: https://www.ncbi.nlm.nih.gov/books/NBK218751/, Role of selenium-containing proteins in T-cell and macrophage function. Selenium and coronary heart disease: a meta-analysis: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1829306/, Zuzanna Sabina Goluch-Koniuszy (2008). But how much do you actually need to feel seleniums benefits? Anish Devji Bhalsod Many health benefits have been associated with selenium. Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Your horse is getting .045 mg of Se in every pound of hay he eats. Symptoms of selenium toxicity include a garlicky odour in the breath, fatigue, gastrointestinal symptoms, transverse lines on the nails, alopecia, and peripheral . While that depends on your age, according to the NHS the recommended amount of selenium to be consumed a day by men is 0.075mg, or 75 micrograms (g). When selenium binds together with heavy metals, e.g. As we noted above, in the UK, the average consumption of selenium was dramatically below the recommended daily intake. Dietary factors inhibiting selenium uptake Some minerals and other dietary components may inhibit the uptake of selenium. These cookies will be stored in your browser only with your consent. This can cause damage to the hair and nails and can lead to symptoms including diarrhoea, nausea, and fatigue. Adults and children 14 and up. Follow your doctor's orders or the directions on the label. Getting too much selenium over time can cause the following: Although some studies have used doses of 200 mcg, there is some evidence that this amount could increase your risk for diabetes. Keep from freezing. Available from: https://www.ncbi.nlm.nih.gov/books/NBK482260/, https://ods.od.nih.gov/factsheets/Selenium-HealthProfessional/, Get the best price on Performance Lab PL-Immune here. If you are a Mayo Clinic patient, this could Levels above this are considered to be toxic. 12 pounds times .045 mg Se per pound = .54 mg of Se consumed daily. Do not refrigerate. 70 micrograms/day. If you have any questions or concerns, please talk to your doctor. Infants 12-23 months 20 micrograms. Plasma or serum selenium concentrations of 8 g/dL or higher typically meets needs for selenoprotein synthesis. If you miss a dose of this medicine, take it as soon as possible. The daily 50-milligram high selenium yeast tablet brought the participants up to the lower limit of the putative beneficial range. Receive unique insights, advice and exclusive offers. Symptoms of selenium toxicity include a garlicky odour in the breath, fatigue, gastrointestinal symptoms, transverse lines on the nails, alopecia, and peripheral neuropathy. These include hair loss and nausea, as a result of the condition known as selenosis. For selenium: For oral dosage form (tablets): To prevent deficiency, the amount is based on normal daily recommended intakes: Adult and teenage males40 to 70 micrograms (mcg) per day. J Dooley. Necessary cookies are absolutely essential for the website to function properly. The recommended dose is 100 mcg to 200 mcg per day. Children birth to 3 years of age10 to 20 mcg per day. Plasma levels of Selenoprotein P Selenoprotein P is the most abundant selenoprotein in plasma, accounting for approximately 25% 50% of the total selenium in the plasma. However, none of these studied the effect of selenium supplements. Selenium metabolism and platelet glutathione peroxidase activity in healthy Finnish men: Effects of selenium yeast, selenite, and selenate. Unfortunately, while selenium deficiency can have its symptoms, overuse can cause its own problems too. We use cookies on our website to give you the most relevant experience by remembering your preferences and repeat visits. An estimation of selenium requirements for New Zealanders. A 2008 paper, meanwhile, concluded that there is still insufficient evidence to associate selenium with cancer risk. Women who are pregnant and lactating need about 60 and 70 micrograms daily, respectively. Putative beneficial rangefor plasma selenium status Hurst and Fairweather-Tait et al, researchers based at Norwich Medical School, University of East Anglia, in the United Kingdom have suggested that the putative beneficial range lies between 120 and 150 nanograms of selenium per milliliter of plasma [Hurst 2010]. This gives us a starting point. (2012). Review of selenium and prostate cancer prevention: https://www.ncbi.nlm.nih.gov/pubmed/23725109, Ujang Tinggi (2008). See all Selenium is found naturally in foods or as a supplement. Studies have shown that above 200 mcg per day, it can be toxic. Research continues to observe that further studies into the role of selenium supplements are needed. Effects of selenium deficiency on tissue selenium content, deiodinase activity, and thyroid hormone economy in the rat during development: https://www.ncbi.nlm.nih.gov/pubmed/10875250, NHS Vitamins and minerals: https://www.nhs.uk/conditions/vitamins-and-minerals/others/, National Institutes of Health (NIH) Selenium: https://ods.od.nih.gov/factsheets/Selenium-HealthProfessional/, Nutrition Foundation Selenium: https://nutritionfoundation.org.nz/nutrition-facts/minerals/selenium, From our health centre. When researchers examined whether selenium had any effect on skin cancer, they found that people who took as little as 200 mcg of selenium per day for more than 7 years had a significantly higher risk of developing type 2 diabetes. Commentdocument.getElementById("comment").setAttribute( "id", "a108014920e5e6267b7261079fab2ada" );document.getElementById("b08a9cbeb4").setAttribute( "id", "comment" ); Save my name, email, and website in this browser for the next time I comment. In the spectrum of vitamins and minerals, we have certain ones that the body requires in larger amounts for optimal function. Bgel, S., Larsen, E. H., Sloth, J. J., Flytlie, K., Overvad, K., Steenberg, L. C., & Moesgaard, S. (2008). Seleniums health benefits, like those of all minerals and vitamins, come from having the right amounts. It is especially rich in selenocysteine, the 21st amino acid that is a vital component of the selenoproteins. Try to limit yourself to one to three Brazil nuts per day to be safe. The safe upper limit for selenium is 400 micrograms a day in adults. . Newer Post . Am. In this article, were going to look at the science behind seleniums supposed benefits. This website uses cookies to improve your experience while you navigate through the website. The amount of medicine that you take depends on the strength of the medicine. How much selenium you need per day changes according to your age, sex and life-stage. Nutrition of women with hair loss problem during the period of menopause: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4828511/, Hind M. Almohanna,Azhar A. Ahmed,John P. Tsatalis, andAntonella Tosti (2018). J. Clin. Alfthan G., Aro A., Arvilommi H., Huttunen J.K. (1991). Effects of selenium deficiency on tissue selenium content, deiodinase activity, and thyroid hormone economy in the rat during development: a 2001 paper by the British Nutrition Foundation, according to New Zealands nutritional agency, https://www.ncbi.nlm.nih.gov/pubmed/22705420?dopt=Abstract, https://www.medsafe.govt.nz/profs/puarticles/sel.htm, https://www.nutrition.org.uk/attachments/145_Selenium%20and%20health.pdf, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4726178/, https://www.ncbi.nlm.nih.gov/pubmed/23725109, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2698273/, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1829306/, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4828511/, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380979/, https://www.ncbi.nlm.nih.gov/pubmed/10875250, https://www.nhs.uk/conditions/vitamins-and-minerals/others/, https://ods.od.nih.gov/factsheets/Selenium-HealthProfessional/, https://nutritionfoundation.org.nz/nutrition-facts/minerals/selenium. To make it easier, figure out how much selenium he is getting daily in 1 lb of hay: Divide .1 mg by 2.2 lbs = .045. Any cookies that may not be particularly necessary for the website to function and is used specifically to collect user personal data via analytics, ads, other embedded contents are termed as non-necessary cookies. Adults get about 40 to 50 micrograms of selenium per day. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine. Over time, high doses of selenium can be toxic. One study of elderly volunteers found that supplementation with 400 g of selenium per day significantly increased total T-cell count by more than 27% compared to the placebo, which was attributed to an increase in subsets of CD4+ T cells and increased cytotoxicity of natural killer cells 3. High doses of selenium can cause significant side effects including nausea, vomiting, nail changes, loss of energy, and irritability. These cookies do not store any personal information. Copyright 2022 IBM Watson Health. 1998-2022 Mayo Foundation for Medical Education and Research (MFMER). 14, Trace Elements. Taking lower doses long-term can increase the risk of developing diabetes. Selenium and Metabolic Disorders: An Emphasis on Type 2 Diabetes Risk. However, selenium deficiency is rare, particularly in the United States. The recommended selenium dosage to take will vary depending on your reasons for using this supplement and current health status. Ten weeks of supplementation with a daily 100-microgram high-selenium yeast tablet raised the participants plasma selenium concentrations to an average of 152.0 nanograms per milliliter. Your email address will not be published. Nutrients, 8(2), 80. When taken by mouth: Selenium is likely safe when taken in doses less than 400 mcg daily, short-term.But selenium is possibly unsafe when taken in high doses or for a long time. The importance of selenoproteins and the associated enzymes to human health is evident by looking at the effects of single nucleotide polymorphisms (SNPs) in selenoprotein genes on disease risk or mortalityCVD, cancer, stroke, type 2 diabetes, metabolic syndrome, and more. A deficiency of this critical mineral exacerbates the redox by-product toxicity and oxidative damage to cell membranes 6. Sign up for emails to get 10% off your first order. To provide you with the most relevant and helpful information, and understand which Currently, the recommended dietary intake (RDI) for selenium is 55mcg with a tolerable upper intake level of 400mcg per day 7. Taken in combination, the two supplements seem to give a better health outcome [Alehagen]. Its the most comprehensive dynamic immune support supplement on the market designed to activate immune cells and support all types of immune responses. The Role of Vitamins and Minerals in Hair Loss: A Review: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380979/, J M Bates,V L Spate,J S Morris,D L St Germain,V A Galton (2000). The proper daily dosage of selenium for normal people? Consequently, plasma glutathione peroxidase seems to reach its optimal activity at levels below the levels that are thought to correlate with reductions in cancer risk [Hurst 2010]. Daily Health Ten weeks of supplementation with a daily 100-microgram high-selenium yeast tablet raised the participants' plasma selenium concentrations to an average of 152.0 nanograms per milliliter. This amount fulfills 28 percent of the Food and Nutrition Board's recommended daily allowance of selenium for healthy adult men and women following a 2,000-calorie diet. Currently, the recommended dietary intake (RDI) for selenium is 55mcg with a tolerable upper intake level of 400mcg per day 7. While this might be great news for men suffering from male pattern baldness, whats important to note is that too much of the mineral can result in the reversal of seleniums benefits. Investigating exactly this, a 2011 study involving over 4000 people found that people who took mineral supplements (including selenium) increased their verbal memory and executive functioning. Lets look at the numbers from published research and see what sense we can make of them. Selenium occurs naturally in small amounts in foods, with the exception of Brazil nuts, which contain an abnormally high amount of the mineral. 68 percent of us, perhaps? And according to a 2001 paper by the British Nutrition Foundation, selenium intake has dropped hugely over the last decades in the UK. 55 micrograms/day. We'll assume you're ok with this, but you can opt-out if you wish. Anything above that is considered an overdose. Children 7 to 10 years of age . Pregnant females65 mcg per day. Journal of Trace Elements in Medicine and Biology, 31157-162. Check out these best-sellers and special offers on books and newsletters from Mayo Clinic Press. According to one 2016 study which included 69 prior studies, involving over 300,000 people a link was found between the amount of selenium in your bloodstream and your risk of cancer. But opting out of some of these cookies may affect your browsing experience. These cookies will be stored in your browser only with your consent. Glutathione peroxidase usually accounts 10% to 30% of the total selenium in the plasma. Wouldnt it be better to look at plasma levels of some of the important selenoproteins? This shows that there are many food sources that provide you with ample quantities of your required minerals. National Research Council (US) Committee on Diet and Health. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes. Selenium and coenzyme Q10 interrelationship in cardiovascular diseasesA clinicians point of view. Adults, teenagers, and childrenTreatment dose is determined by prescriber for each individual based on severity of deficiency. (1-2 servings/day) and juice (1 small glass/day). Individually, they all exert specific roles, such as 2: When we dive into this further, we can see that selenium plays an important role in mitigating oxidative stress, which is linked to high levels of inflammation, immune responses, and disease. Adult and teenage females45 to 55 mcg per day. Apparently they could not get enough without supplements. Extreme differences in exposure were found across the world, even within countries, which enables the understanding of the correlation between selenium deficiency and human disease prevalence. Older Post One poached egg contains 21g of selenium, while 100g of tuna contains 47g. How much Selenium do we need each day? The Food and Nutrition Board (FNB) at the Institute of Medicine of the National Academies recommends that healthy people age 14 years and older get 55 mcg of selenium daily from all sources. The supplements lowered levels of total plasma cholesterol and non-high-density-lipoprotein . This site complies with the HONcode standard for trustworthy health information: verify here. GPhC Registration: 2086847, Answer a few questions, get personalised treatment recommendations. This cookie is set by GDPR Cookie Consent plugin. Plasma selenoprotein levels Selenium carries out its biological functions primarily as a component of the amino acid, selenocysteine. But, remember, these results reported by Hurst, Fairweather-Tait, et al were obtained in men and women of Caucasian background aged 50 64 years who had a clearly low baseline plasma selenium concentration. The safe upper limit for selenium is 400 micrograms a day in adults. * These statements have not been evaluated by the Food and Drug Administration. Biochemical differences affecting selenium uptake The ability to absorb selenium from the digestive system varies from individual to individual. More studies are needed to understand the meaning behind these findings. Something that looked positive was an overview of 25 different studies which found that, on average, a 50% increase in selenium concentration in the blood led to a 24% decrease in the risk of coronary heart disease. WATER. J. Clin. Other effects of selenium deficiency include: Selenium is widely available in food sources that are both animal and plant-based. Brazil nuts, for example, include very high quantities of selenium as much as 48g per nut, according to New Zealands nutritional agency. information submitted for this request. information is beneficial, we may combine your email and website usage information with But it does look hopeful that selenium may benefit your cardiovascular health. Optimal glutathione peroxidase activity seems to reach a plateau at plasma concentrations in the range from 70 90 nanograms per milliliter. In the USA 1993 China study, the group taking vitamin E, beta-carotene and selenium showed more than 30 per cent less cancers. Plasma and platelet levels of glutathione peroxidase Hurst, Fairweather-Tait, et al give us some numbers that we can look at. RDA: The Recommended Dietary Allowance (RDA) for adult men and women 19+ years of age is 55 micrograms daily. However, there is considerable biochemical variation amongst us humans. How many of us are approximately normal? Portions of this document last updated: Nov. 01, 2022. The cookie is used to store the user consent for the cookies in the category "Analytics". Interestingly, however, no benefit was found by taking selenium supplements. Too much selenium can be toxic, so don't overdo it keep your daily intake below 400 mcg. One of seleniums benefits is thought to be a prevention of cardiovascular disease. Taking doses above . Compare with plasma glutathione peroxidase activity seeming to plateau at 90 nanograms per milliliter [Duffield 1999]. Advertising revenue supports our not-for-profit mission. 4 What is the danger of too much selenium in the body? Generally, official recommendations suggest that anything over 400g a day is too much. By clicking Accept All, you consent to the use of ALL the cookies. These supplements usually contain between 100-400 micrograms of selenium per dose (the Tolerable Upper intake Level is 400 micrograms). However, as its a chemical element, its richness in certain foods will depend on where in the world theyre produced. And we believe it's best to get this mineral from food, not supplements. This content does not have an Arabic version. Among the better known selenoproteins are the glutathione peroxidases, the thioredoxin reductases, the iodothyronine deiodinases, and selenoprotein P. By this time, you may be wondering why are we looking so much at plasma selenium levels? Anything above that is considered an overdose. For those of who dont know how much selenium we are getting in our food, perhaps a good place to start is to get a plasma or serum Se test? Breastfeeding teens & women. Making healthier easier, every day. We use cookies to analyse data and personalise your visit, learn more in our. However, some studies suggest the RDI is on the low side and set the minimum requirement at 90 mcg daily per adult. Research there suggests that selenium has a 20 per cent positive effect on cancer risk. For example, there is some evidence that the response to selenium intakes may vary according to sex [Ogawa-Wong]. This content does not have an English version. It may reduce your risk of cancer and boost your immune system. Symptoms of selenium toxicity include a garlicky odour in the breath, fatigue, gastrointestinal symptoms, transverse lines on the nails, alopecia, and peripheral . The daily 100-microgram high selenium yeast tablet brought the participants up to the upper limit of the putative beneficial range. Performance cookies are used to understand and analyze the key performance indexes of the website which helps in delivering a better user experience for the visitors. Good sources of selenium include: brazil nuts; fish; meat; eggs; How much selenium do I need? At this point, the mineral becomes toxic. High blood levels of selenium can result in selenosis, with gastrointestinal distress, hair loss, white spots on nails, fatigue, and irritability. It should never be relied upon for specific medical advice. Yohimbe / Yohimbine Overview, Health Benefits & Side Effects, Understanding Thyroid Function Test Results. Schrauzer identified a lengthy list of minerals and heavy metals in food and water that selenium will interact with, many of them antagonistic to selenium. All rights reserved. It may help asthma symptoms and prevent cognitive decline. Some patients will benefit from even higher dosages. Rodent studies find that mice with selenoprotein-less T-cells exhibit reduced pools of mature and functional T-cells in lymphoid tissues along with impaired T-cell-dependent antibody responses. Remember: we humans need adequate plasma selenium concentrations for optimal antioxidant and anti-viral and anti-carcinogenic protection [Schrauzer 2009]. Whether this improvement was seleniums benefit alone or one of the other minerals included, is unclear. And although selenium is a trace mineral thats only required in small amounts, when it comes to supporting immune function, this guy is big. It is mandatory to procure user consent prior to running these cookies on your website. Selenium intakes and type-2 diabetes - Seleniumfacts, Selenium: protection against the accumulation of mercury in the body - Seleniumfacts, Selenium Supplementation and Alzheimers Disease, Selenium and Viruses and Viral Infections, Selenium Deficiency and Thyroid Disorders, Impact of Selenium Status on Biological Aging, Selenium and Coenzyme Q10 Supplementation To Prevent Heart Disease, Dr. Gerhard N. Schrauzer renowned selenium researcher, Selenium and statin medications and selenoproteins, Circulatory selenium concentrations and Alzheimers disease - Seleniumfacts, Selenium and Alzheimers disease and cognitive decline. Diet and Health: Implications for Reducing Chronic Disease Risk. Research has shown that people with Alzheimers have lower levels of selenium in their blood. Infants 6-11 months 15 micrograms. Functional cookies help to perform certain functionalities like sharing the content of the website on social media platforms, collect feedbacks, and other third-party features. It wasnt until the 1950s that the importance of selenium was recognized. This is useful information. mercury or cadmium, the effect is a beneficial detoxification. Review/update the In: StatPearls (Internet). Avoid sugary drinks. Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. Researchers refer to this as the hierarchy of selenoprotein synthesis.. More than 500 million people are affected by selenium deficiency around the world due to inadequate intake, especially where soil concentrations are low, which affects the quantities present in food 6. Try to limit your Brazil nut intake to one to three per day. Selenium supplementation has been shown to exhibit immunostimulant effects, such as enhancing the proliferation of activated T cells, increasing cytotoxic lymphocyte-mediated tumor cytotoxicity, and natural killer cell activity 2. For women, that number is 60g. The safe upper limit for selenium is 400 micrograms a day in adults. Larsen, E. H., Hansen, M., Paulin, H., Moesgaard, S., Reid, M., & Rayman, M. (2004). Journal Of AOAC International, 87(1), 225-232. Breast-feeding females75 mcg per day. What can we do with these numbers? You'll soon start receiving the latest Mayo Clinic health information you requested in your inbox. Normal people? But what happens when you dont get enough selenium? Washington (DC): National Academies Press (US); 1989. The dietary reference value (DRV)* for healthy adults (over the age of 18), including during pregnancy, is 70 g of selenium per day. Many selenium studies have been done in mostly Caucasian samples drawn in the United States and Europe. What is meant by the competitive environment? In humans, the primary role of selenium is attributed to the function of 25 selenoproteins that have selenocysteine at their active center 2. Caution: Many factors affecting selenium status Remember, it is difficult to specify which amounts of daily selenium intake will result in which beneficial plasma (or serum) selenium levels for all individuals. Brazil nuts contain a . However, this does not necessarily show that increasing selenium brings benefits to your cognitive capacities. Ten weeks of supplementation with a daily 50-microgram high-selenium yeast tablet raised the participants plasma selenium concentrations to an average of 118.3 nanograms per milliliter. The more veggies and the . Background note: Glutathione peroxidase is the name of a whole family of antioxidant enzymes that protect the cells and tissues against oxidative damage caused by harmful free radicals. If your dose is different, do not change it unless your doctor tells you to do so. The average baseline plasma selenium concentration in the study participants was 95.7 nanograms per milliliter, clearly below the suggested beneficial range. Arent getting enough sleep? Thats your minimum, but its estimated that on average in the UK, people only receive 39g a day. The American Journal of Clinical Nutrition, 96(1), 111-122. Eating too many Brazil nuts can be harmful due to their high selenium content. As we just mentioned, the thing with selenium is that tissues that maintain high concentrations of selenium will maintain their selenium levels during deficiency, but tissues such as those of the immune system will exhibit a more rapid decline in bioavailable selenium during deficiency, ultimately resulting in decreased synthesis of selenoproteins 5. Children 2-5 years 25 micrograms. Critical Reviews in Biotechnology, 29(1), 10-17. According to the US government, adults should not consume over 400g of selenium in a day. Trace elements, like selenium, are minerals that are present in living tissues in small amounts that function primarily as catalysts in enzyme systems 1. An adult should take in about 70 micrograms of selenium per day. Selenium deficiency is . Getting too much selenium over time can . Out of these, the cookies that are categorized as necessary are stored on your browser as they are essential for the working of basic functionalities of the website. All rights reserved. And because T cells are especially sensitive to levels of oxidative stress, selenoprotein-deficient T cells cannot proliferate in response to T-cell-receptor stimulation because of the inability to suppress the production of reactive oxygen species (free radicals) 4. . Review of selenium and prostate cancer prevention: V A Galton (2000). In particular, be careful with Brazil nuts; because they contain so much seleniumas much as 90 mcg per nutyou can actually trigger selenium toxicity by . The recommendation goes up to 60 mcg per day if you're pregnant and 70 mcg per day if you're breastfeeding. Nutr. So, what are seleniums health benefits? Dr. Donaldson found that he had to supplement the cancer patients with at least 200-600 micrograms of selenium per day, and in some cases 2,000 micrograms of selenium per day were required to obtain normal blood levels of selenium. That's your minimum, but it's estimated that on average in the UK, people only receive 39g a day. Nutr. However, some studies suggest the RDI is on the low side and set the . The reason selenium is linked to a stronger immune response is because selenoproteins are essential for activated T-cell function. Studies consistently suggest that adequate dietary selenium is essential for the activity of virtually all arms of the immune system, and if not getting adequate intake from diet, supplemental selenium can also improve immune function. Selenium: its role as antioxidant in human health: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2698273/, Gemma Flores-Mateo,Ana Navas-Acien,Roberto Pastor-Barriuso, andEliseo Guallar(2007). Ogawa-Wong, A. N., Berry, M. J., & Seale, L. A. This cookie is set by GDPR Cookie Consent plugin. It may also participate in other important metabolic interactions with a number of hazardous elements, including mercury, cadmium, and arsenic. document.getElementById( "ak_js" ).setAttribute( "value", ( new Date() ).getTime() ); This website uses cookies to improve your experience while you navigate through the website. This represents 364% of the US Recommended Dietary Allowance for selenium, which is 55 mcg. Under normal conditions, selenium acts in combination with vitamin E to maintain the integrity of cell membranes, participating in redox reactions with hydrogen peroxide-producing glutathione. Selenium in the environment, metabolism and . In addition, supplementation of selenium in the form of dietary supplements can be very useful. While the entire scope of roles for selenium isnt well known or understood, the only major biochemical function recognized for selenium in all mammals is its role in the peroxide-destroying enzyme glutathione peroxidase 1. You feed your horse 12 lbs of hay per day. How much selenium should you take? The maximum safe daily intake is 400g. These cookies track visitors across websites and collect information to provide customized ads. Advertisement cookies are used to provide visitors with relevant ads and marketing campaigns. The same is true of New Zealand, where efforts were made to import selenium-rich grains. 40 micrograms/day. Alehagen, U., & Aaseth, J. Once we have an idea of our plasma selenium status, we can consider how much daily supplementation we think we need: 50 or 100 micrograms per day? health information, we will treat all of that information as protected health To prevent deficiency, the amount is based on normal daily recommended intakes: Adult and teenage males40 to 70 micrograms (mcg) per day. Thus, sufficient intake of selenium through diet and selenoproteins is not only important for initiating or enhancing immune function, but theyre also involved in immunoregulation, which is essential for preventing excessive immune responses that can contribute to the development of autoimmunity or chronic inflammation. You may opt-out of email communications at any time by clicking on At the same time, though, selenium has become increasingly popular in the world of dietary supplements particularly among those seeking the many health benefits that have been attributed to it. The recommended intake per day differs between different age groups: Gender / Group / Age Recommended intake. Causes of selenosis range from ingestion of excessive selenium , as is the case of regular snacking on Brazil nuts which could contain up to 90 g of selenium per nut. Your body doesnt produce it, yet, without it, you simply wouldnt function properly. There are just too many factors that influence the uptake of the selenium in our food and in our selenium supplements. While selenium plays an important role in many of the bodys processes, scientific studies have not found conclusive evidence that boosting your intake necessarily improves your health. While selenium toxicity is rare, it's important to stay close to the recommended amount of 55 mcg per day and never exceed the tolerable upper limit of 400 mcg per day . Analytical cookies are used to understand how visitors interact with the website. Selenium has a narrow therapeutic index, and doses of under 100 mcg per day may not be sufficient for improving Hashimoto's symptoms and markers, while doses in excess of 800 mcg per day can be toxic. Junshi Chen (2012). An estimation of selenium requirements for New Zealanders. In 2010, Hurst and Fairweather-Tait and their colleagues reported the results of a randomized controlled trial of supplementation with a high selenium yeast preparation in healthy British men and women aged 50 64 years. Learn more about this trace mineral. Is 55 mcg of selenium too much? You shouldn't take too much. Plasma selenium levels and risk of prostate cancer In 2012, Hurst and Fairweather-Tait and their colleagues published the results of a systematic review and meta-analysis of research results from randomized controlled trials, case-control studies, and prospective cohort studies. (2010). You can safely take in up to 400 mcg per day between food and supplements. There is a problem with Pregnant teens & women. Plasma selenoprotein P concentration is arguably a better index of selenium status sufficiency than glutathione peroxidase because the glutathione peroxidase activity reaches optimal levels at lower plasma concentrations. This is because, in too high quantities, selenium can be toxic and can lead to a condition known as selenosis. Yes, we humans are more the same in many ways than we are different. At present, the best formulation for reducing the risk of cancer is the organic high-selenium yeast formulation. The average American consumes 75 mcg per day. Stressed out? What is the normal selenium level in the human body? If we combine this information with your protected Other uncategorized cookies are those that are being analyzed and have not been classified into a category as yet. For those of you considering selenium supplements, ensuring that you stay within recommended dosages is crucial. Copyright2022Manual. Food & Nutrition Research, 52doi:10.3402/fnr.v52i0.1642. 75g of selenium a day is the recommended amount in the UK, and that can be quite easily consumed in your diet without the need for supplements. Their meta-analysis showed that plasma selenium concentrations in the range from 120 nanograms per milliliter up to 170 nanograms per milliliter were associated with decreased risk of prostate cancer [Hurst 2012]. How much selenium per day is toxic? information highlighted below and resubmit the form. Similarly, it is asked, how much is too much selenium per day? This product is not intended to diagnose, treat, cure or prevent any disease. Average daily recommended amounts are listed below in micrograms (mcg). Duffield A.J., Thomson C.D., Hill K.E., Williams S. (1999). This has reached the point which, at publication, selenium consumption was almost only half of the recommended daily amount. The Dietary Supplements Regulations 1985 require supplements to have a maximum adult dose of 150g/day. What do the numbers from selenium studies say? The recommended DV for selenium is 55 mcg per day for most adults. Anything above that is considered an . The amount of selenium that you need each day depends on your age. Were always looking for ways to optimize body performance and keep ourselves as healthy as possible, and doing that starts with supporting immune function. Safe Dosage The Institute of Medicine sets the recommended dietary allowances of selenium at 55 micrograms daily for the . You also have the option to opt-out of these cookies. The following information includes only the average doses of these medicines. You also have the option to opt-out of these cookies. Children 7 to 10 years of age30 mcg per day. For adults, the RDA for selenium is 55 mcg per day. Long story short, the biological effects of selenium are mainly seen through its incorporation into selenoproteins, and selenoproteins are heavily involved in the activation, proliferation, and differentiation of cells that drive both innate and adaptive immune responses 5. As a result, youll find it in all sorts of different foods, including fish, cereals, pasta, and, especially, brazil nuts. In some areas of rural China, for example, people have historically suffered from selenium deficiency as a result of the low quantities of the mineral in the local soil. Do not double doses. A deficiency of selenium has also been shown to turn harmless viruses into virulent pathogens. During lactation, needs can go up to 85 g of selenium per day. The cookies is used to store the user consent for the cookies in the category "Necessary". Unfortunately, they all contribute to a weakened immune system. It often takes several years to develop and usually occurs in areas with severely low selenium content in the . The cookie is used to store the user consent for the cookies in the category "Performance". There are no known safe levels of selenium. In the UK, the recommended maximum intake of selenium is 75g (microgram), or 0.075mg a day. Selenoprotein P functions as an antioxidant; it has other biological functions as well. In one randomized, placebo-controlled study, for example, 474 healthy adults aged 60 to 74 years with a mean baseline plasma selenium concentration of 9.12 mcg/dL were supplemented with 100, 200, or 300 mcg selenium per day or placebo for 6 months . Xiao-Hou Wu (2013). Children 4 to 6 years of age20 mcg per day. But how much do you need per day to feel seleniums health benefits? The best way to ensure you're getting enough selenium is to check your blood level. privacy practices. Age may well play a role in the response to selenium intakes [Thompson]. Treasure Island (FL): StatPearls Publishing; 2021 Jan-. Government guidelines recommend 55 micrograms (mcg) of selenium per day, but for optimal health and disease prevention, up that to 200 mcg per day. It also helps prevent damage to cells and tissues. Absorption, excretion, and retention of selenium from a high selenium yeast in men with a high intake of selenium. The recommended dose is 100 mcg to 200 mcg per day. Sign up for free, and stay up to date on research advancements, health tips and current health topics, like COVID-19, plus expertise on managing health. The recommendation goes up to 60 mcg per day if you're pregnant and 70 mcg per day if you're breastfeeding. Required fields are marked *. Excess selenium causes cirrhosis and is linked to non-alcoholic fatty liver disease (NAFLD). Yet, while such a link between the disease and the mineral would be exciting, the evidence is not definitive. With each serving youre getting: Supporting your immune system in a world that seems to always be working against it can be challenging, but if you know what your body needs for optimal function, its a cinch. Other studies have shown similarly mixed results. Performance Lab Ltd, 7 Clarendon Place, Royal Leamington Spa, CV32 5QL, United Kingdom. Disclaimer: The information in this article and all articles on this web-site is not intended as medical advice and should be used as such. Improved cardiovascular health and healthier hair are both thought to result from the mineral, while it may ease mental decline and reduce the risk of cancer too. Much work has also been done with the population of China where there are both selenium rich areas and selenium deficient areas. For women, that number is 60g. Interestingly, in low selenium supply, synthesis of some selenoproteinsfor example, glutathione peroxidase, GPx4is prioritized over others 2. Selenium Deficiency. While adding selenium into your diet can make a big impact for the immune system, giving it a bigger boost with PL-Immune containing selenium and five other powerful immune-boosters is a surefire way to keep you protected during even the toughest immune challenges. Duffield, A. J., Thomson, C. D., Hill, K. E., & Williams, S. (1999). While we've ensured that everything you read on the Health Centre is medically reviewed and approved, information presented here is not intended to be a substitute for professional medical advice, diagnosis, or treatment. 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